These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Suppression of anti-hapten IgE and IgG antibody responses by isologous anti-idiotypic antibodies against purified anti-carrier (ovalbumin) antibodies in BALB/c mice.
    Author: Blaser K, Nakagawa T, de Weck AL.
    Journal: J Immunol; 1981 Mar; 126(3):1180-4. PubMed ID: 7462630.
    Abstract:
    The studies described here show that BALB/c mice actively producing isologous anti-idiotypic antibodies (ald) after immunization with purified, syngeneic anti-OvA antibodies exhibit depressed anti-hapten and anti-carrier IgE and IgG antibody responses, provided that hapten-OVA conjugates are used to mount the immune responses. We suggest that carrier-specific helper T cells (CTh) for IgE and IgG antibody production carry idiotypes similar or identical to those among purified anti-OVA IgG antibodies. The mode of regulation of immune responses by anti-carrier-ald may be different from that exerted by anti-hapten-alD. Although anti-carrier-ald may block or deplete CTh and thereby prevent help for immunoglobulin production by B cells, anti-hapten-ald may induce T suppressor cells (Ts).
    [Abstract] [Full Text] [Related] [New Search]