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  • Title: Regional distribution and production rate of 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) in rat brain.
    Author: Kohno Y, Tanaka M, Nakagawa R, Toshima N, Nagasaki N.
    Journal: J Neurochem; 1981 Jan; 36(1):286-9. PubMed ID: 7463053.
    Abstract:
    The levels of noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) in 15 brain regions showed a parallel distribution in male Wistar rats. The differences in regional distribution of MHPG-SO4 were similar to those in the rate of NA turnover reported by other investigators. The accumulation rates of MHPG-SO4 during 45 and 90 min after probenecid injection significantly correlated to the steady state levels of MHPG-SO4 in nine regions studied. With the results, the regional levels of MHPG-SO4 either in untreated or in probenecid-treated rats, are considered to be a useful index of NA turnover.
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