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  • Title: [Electroclinical and CAT-encephalographic symptomatology of lipomas of the corpus callosum].
    Author: Gastaut H, Iemolo F, Gastaut JL, Regis H.
    Journal: Riv Neurol; 1980; 50(3):167-78. PubMed ID: 7466214.
    Abstract:
    An analysis of four cases with lipomas of the corpus callosum with epilepsy and of some data in the literature has led to the following conclusions: 1) Epilepsy: a nearly constant feature is often severe always partial and begins before the age of fifteen; 2) Pathophysiology of the seizures: abandoning the classic theory that they depend upon an infiltration of the cingulate gyri by fibrous tissue growing out from the capsule of the lipoma, the authors consider that the essential mechanism is represented by the interhemispheric disconnection. This latter is responsible for a facilitory and disinhibitory action which would favour the appearance of seizures under the effects of an epileptogenic lesion, the effect of which would remain sub-threshold in the presence of an intact corpus callosum, playing its normal inhibitory role.
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