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  • Title: Evidence against vitamin K deficiency in normal neonates.
    Author: Malia RG, Preston FE, Mitchell VE.
    Journal: Thromb Haemost; 1980 Dec 19; 44(3):159-60. PubMed ID: 7466743.
    Abstract:
    Umbilical cord plasmas from 24 normal full-term neonates were studied. We confirmed the prolonged prothrombin time and low levels of Vitamin K dependent clotting factors previously described (1), but using a number of recently developed immunological and coagulation techniques we could find no evidence of vitamin K deficiency. We conclude that the decreased levels of vitamin K dependent clotting factors of normal neonates are the result of decreased synthesis by the immature liver and that it is questionable whether vitamin K prophylaxis is necessary for these infants.
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