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  • Title: [Anovulation syndrome in nulligravidae following intake of hormonal contraceptives (author's transl)].
    Author: Müller R, Alexander H, Glück S, Herter U.
    Journal: Zentralbl Gynakol; 1980; 102(1):33-41. PubMed ID: 7467923.
    Abstract:
    Evaluated in this paper is clinical experience recorded from 70 young women, aged between 14 and 27 years, with post-pill syndrome. The aetiology of post-pill amenorrhoea was found to be closely related to lability of cycle prior to pill-taking. Nearly 60 per cent of all patients had used Non-Ovlon. 10 patients had used Sequenz-Ovosiston. The prognosis of iatrogenic normogonadotrophic ovarian insufficiency was found to depend on the basal oestrogen level, reaction of corpus endometrium, and serum prolactin. Pregnancy was successfully induced in 53 per cent of all patients who wanted to have a child. The aboration rate accounted for 7.4 per cent. Clinical examination of the newborns did not give any clue as to accumulation of congenital malformations. Roughly 40 per cent of all patients remained to be anovulatory, in spite of intensive treatment. 70 women were treated for amenorrhea which occurred after having used O.C.s (oral contraceptives) (41 Non-Ovlon, 16 Ovosiston, 10 Sequence Ovosiston, and 3 Gravistat). The patients were given 2 tablets of chlormadinon or Ovosiston monthly; those who wanted to become pregnant received clomiphene on the 5th-9th days of the menstrual cycle. 2/3 of the patients had had stable menstrual cycles before O.C. use; these patients more often became pregnant. Age and length of O.C. use could not be correlated to the subsequent incidence of pregnancy. Estrogen, FSH, and LH values were within normal ranges. Hyperprolactinemia was found in 48% of the 23 who had post-pill amenorrhea; 6 of these had a galactorrhea-amenorrhea syndrome, and 1 a pituitary tumor. Endometrial currttage smears were taken from 31 patients: in 23 cases advanced proliferation without or with little functional capacity was observed, in 7 cases a severe endometrial depression was found, and in 1 case a secretory phase was observed. Ovulation was induced in 23 of the 31 patients to whom Clomiphene had been administered; in 12 cases pregnancy occurred. Of 51 patients, 27 became pregnant, half within the first half year of treatment; 2 patients had twins, 2 had spontaneous abortions.
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