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  • Title: Monitoring of blood coagulation in open heart surgery. I. Effects of conventional dosages of heparin and protamine.
    Author: Dercksen SJ, Linssen GH.
    Journal: Acta Anaesthesiol Belg; 1980; 31(2):113-9. PubMed ID: 7468137.
    Abstract:
    In twenty unselected patients coming for surgery with cardio-pulmonary by-pass coagulation studies were performed. Laboratory results before and after by-pass were compared with serial measurements of ACtivated Clotting Times (ACT) during and after operation using conventional dosages of heparin and protamine. Values of ACT's are presented and compared with a previously published protocol according to Bull (1). Monitoring of ACT during operation was found to be easily applicable and highly desirable. Overdosage of both heparin and protamine was suggested as a correctable cause of proven abnormal coagulation after cardio-pulmonary by-pass.
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