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  • Title: Phosphatidylglycerol determination on amniotic fluid 10,000 x g pellet in the prediction of fetal lung maturity.
    Author: Bent AE, Gray JH, Luther ER, Oulton M, Peddle LJ.
    Journal: Am J Obstet Gynecol; 1981 Feb 01; 139(3):259-63. PubMed ID: 7468692.
    Abstract:
    Phosphatidylglycerol and the lecithin/sphingomyelin (L/S) ratio were determined, and the shake test was performed, as indicators of fetal lung maturity, in more than 600 patients. A clinical review of the outcome was made in all patients who underwent delivery within 2 days after collection of amniotic fluid. Correlation was made phosphatidylglycerol, shake test, and L/S ratio results. L/S ratio had a false positive rate of 5%, and a false negative rate of 58.1%. The shake test had a false positive rate of 1.1%, and a false negative rate of 63.5%. Phosphatidylglycerol determination had a false positive rate of 1.8%, and a false negative rate of 26.9%. Phosphatidylglycerol determination is an accurate predictor of fetal lung maturity, and predicts lung immaturity more correctly than do the L/S ratio and shake test.
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