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  • Title: [Haemodilution and duration of action of muscle relaxants (author's transl)].
    Author: Schuh FT.
    Journal: Anaesthesist; 1981 Jan; 30(1):44-5. PubMed ID: 7469004.
    Abstract:
    As indicated by time-effect diagrams the duration of action of the ED90 of succinylcholine (0.3 mg/kg), pancuronium (0.033 mg/kg), and tubocurarine (0.21 mg/kg) was prolonged following preoperative normovolemic haemodilution. This influence is assumed to be due to a lower protein binding and cholinesterase activity, to an increase of cardiac output and muscle perfusion and to a higher occupancy of the receptor at the motor endplate by muscle relaxants.
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