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  • Title: [Obtaining mutants that yield tobramycin in a culture of the producer of a complex of aminoglycoside antibiotics, Streptomyces cremeus var. tobramycini var. nov. 2242].
    Author: Siniagina OP, Lapchinskaia OA, Lavrova-Balashova MF, Nesterova TP, Ponomarenko VI.
    Journal: Antibiotiki; 1980 Dec; 25(12):891-4. PubMed ID: 7469392.
    Abstract:
    The organism producing an aminoglycoside antibiotic complex was subjected to selection with a purpose of obtaining a strain producing tobramycin. Spontaneous and gamma-radiation-induced variation of the strains obtained as a result of a step-wise selection of the tobramycin-producing organism was studied. Correlation between the antibiotic activity levels and morphological features of these strains was shown. 8 physiological groups of mutants were differentiated and characterized as dependent on the ratio of the components in the aminoglycoside antibiotic complex produced by them. A highly productive strain 3406 was selected. The level of tobramycin synthesis by this strain is 10 times higher than that of the initial culture.
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