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  • Title: Exogenous gastrin in rhesus monkeys. The effect of 50% distal small-bowel resection on its rate of disappearance.
    Author: Mackie CR, Lewis MH, Go VL, Moossa AR.
    Journal: Arch Surg; 1981 Mar; 116(3):297-300. PubMed ID: 7469767.
    Abstract:
    The rate of disappearance from the circulation of exogenous heptadecapeptide gastrin was studied before and after 50% distal small-bowel resection in four rhesus monkeys. For each study, venous blood samples were drawn during, and at frequent intervals after, a one-hour peripheral venous infusion of synthetic human gastrin 1 given at a constant rate within the range of 0.4 to 2.4 microgram/hr/kg of body weight. The rate of disappearance of infused gastrin was not affected by small-bowel resection (mean half-time before operation, 2.50 minutes; mean half-time after operation, 2.47 minutes). These data indicate that in the rhesus monkey, the rate of catabolism of exogenous gastrin is not decreased after distal small-bowel resection, and indicate that other mechanisms are responsible for the hypergastrinemia and gastric acid hypersecretion observed in this animal model.
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