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  • Title: Plasmapheresis in systemic lupus erythematosus: a cautionary note.
    Author: Schlansky R, DeHoratius RJ, Pincus T, Tung KS.
    Journal: Arthritis Rheum; 1981 Jan; 24(1):49-53. PubMed ID: 7470171.
    Abstract:
    Plasmapheresis was used as the sole treatment modality in 4 patients with systemic lupus erythematosus. The presence of circulating immune complexes in this group of patients was not predictive of response to plasmapheresis. Lymphocytotoxic antibody levels fell in 3 of the 4 patients, and no consistent changes in T lymphocytes, T lymphocyte subsets, complement, or immunoglobulin levels were observed. Followup during the subsequent 6 months showed deterioration in clinical and laboratory parameters in all 4 patients, and the protocol was discontinued. Plasmapheresis without concomitant therapy may be detrimental to certain patients with systemic lupus erythematosus.
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