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  • Title: [Assay of brain and liver DNA, determination of body growth and of some blood parameters in rats subjected to protein malnutrition during fetal and post-natal development].
    Author: Greco AM, Di Filippo O, Boschi G, de Franciscis A.
    Journal: Boll Soc Ital Biol Sper; 1980 Dec 30; 56(24):2598-604. PubMed ID: 7470306.
    Abstract:
    The Authors studied the effects of proteinic malnutrition when it occurred at various periods in the life of rats: the last 10 days of fetal life; nursing (the first 3 weeks of life); after weaning (up to 42 day). The results show that:--the growth in weight of the animals was severely restrained when protein deficiency occurred in post-natal life;--in any case, the blood levels of hematocrit, hemoglobin and proteins were significantly lowered;--organ functions and development were greatly compromised if malnutrition occurred during the period of their cell division. In fact, a brain damage, estimated by protein and DNA modifications, is the result of protein deficiency in pre-natal and, particularly, in nursing period. The hepatic damage, instead, becomes more evident in post-natal life and specially after weaning since the cell division in the liver continues for a much longer period of time.
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