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  • Title: Effect of oxymetholone on human cyclic haematopoiesis.
    Author: Roozendaal KJ, Dicke KA, Boonzajer Flaes ML.
    Journal: Br J Haematol; 1981 Feb; 47(2):185-93. PubMed ID: 7470391.
    Abstract:
    A 62-year-old woman had recurrent fluctuations of neutrophil, monocyte, reticulocyte and platelet counts with a cycling time of 38.5 d. Periodic fluctuations of granulo-, erythro- and megakaryopoiesis were also demonstrated in her bone-marrow. Oxymetholone reduced the magnitude of the profound cyclic fluctuations in all these cell lines. During treatment a reduced number of in vitro CFU-C of the progenitor myeloid series from the bone marrow was observed. Using the patient leucocytes as feeders for normal control marrow cells, indication was found for a fluctuation in colony stimulating activity in vitro, rising above normal at the nadir of the WBC.
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