These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparative toxicity of detorubicin and doxorubicin, free and DNA-bound, for hemopoietic stem cells.
    Author: Huybrechts M, Trouet A.
    Journal: Cancer Chemother Pharmacol; 1980; 5(2):79-82. PubMed ID: 7471318.
    Abstract:
    We compared the toxicity of detorubicin (DET) and of doxorubicin (DOX) on the hematopoietic stem cells in C57BL6J mice by means of the CFUS and CFUC assays. On an equimolar basis DET appears to be less toxic than DOX for both the pluripotent stem cells and the granulocytic progenitor cells. Moreover, the administration of these anthracyclines as DNA complexes leads to a decreased toxicity to the pluripotent stem cells, while no such attenuated toxic effect is observed in committed stem cells.
    [Abstract] [Full Text] [Related] [New Search]