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  • Title: Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations.
    Author: McKenzie S, Baillie E.
    Journal: Arch Dis Child; 1978 Dec; 53(12):943-6. PubMed ID: 747398.
    Abstract:
    Serum theophylline levels were measured throughout the day in 65 asthmatic children receiving one of two slow-release theophylline compounds. There was a wide interindividual variation in levels obtained with similar doses of pure theophylline, and also a wide intraindividaual variation in levels throughout the day, suggesting that the rates of release and/or absorption of theophylline from these compounds are not uniform. There were fewer side effects associated with taking these compounds than with choline theophyllinate.
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