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  • Title: Liquid ventilation in adults, children, and full-term neonates.
    Author: Hirschl RB, Pranikoff T, Gauger P, Schreiner RJ, Dechert R, Bartlett RH.
    Journal: Lancet; 1995 Nov 04; 346(8984):1201-2. PubMed ID: 7475663.
    Abstract:
    We evaluated the safety and efficacy of partial liquid ventilation in a series of 19 adults, children, and neonates who were in respiratory failure and on extracorporeal life support. During partial liquid ventilation, the alveolar-arterial oxygen difference decreased from 590 (SE 25) to 471 (42) mm Hg (p = 0.0002) and static pulmonary compliance increased from 0.18 (0.04) to 0.29 (0.04) mL cm H2O-1 kg-1 (p = 0.0002). 11 patients (58%) survived. These preliminary data suggest that partial liquid ventilation can be safely used in patients with severe respiratory failure and may improve lung function.
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