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  • Title: Effect of antibody avidity on the induction of renal injury in anti-glomerular basement membrane nephritis.
    Author: Shimizu F, Mossmann H, Takamiya H, Vogt A.
    Journal: Br J Exp Pathol; 1978 Dec; 59(6):624-9. PubMed ID: 747713.
    Abstract:
    Antibodies to glomerular basement membrane (GBM) of the rat could be fractionated according to their avidity by elution from trypsin-digested GBM (bound to Sepharose) with increasing concentrations of KSCN. The percentage of kidney-fixing antibody in each fraction and the degree of proteinuria induced as determined 24 h after injection increased with the avidity of the antibody fraction when equal doses were administered.
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