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  • Title: Strychnine affects catecholamine secretion from bovine adrenal medulla chromaffin cells.
    Author: Dar DE, Zinder O.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1995 Jul; 352(1):11-6. PubMed ID: 7477420.
    Abstract:
    The effect of strychnine on evoked release of catecholamines from a primary culture of bovine adrenal medullary cells was investigated. Strychnine at > 1 microM inhibited catecholamine release stimulated by 10 microM acetylcholine, or 10 microM nicotine, but not by excess K+ (59 mM), the sodium ionophore veratridine (100 microM) or the calcium ionophore A-23187 (10 microM). The inhibitory response elicited by exposure of the cells to strychnine was rapid (< 3 min) and competitive with acetylcholine. High concentrations of acetylcholine (1 mM) completely overcame this inhibition. Strychnine might be acting on a regulatory site of the nicotinic-cholinergic receptor, which is genetically similar to the strychnine-binding 48 KD subunit of the glycine receptor.
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