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  • Title: [Level of atrial natriuretic peptide (ANP) in plasma of patients with chronic renal failure during hemodialysis].
    Author: Grzeszczak W, Kowalska K, Zukowska-szczechowska EA, Kowalski D, Snit M, Sornek E.
    Journal: Pol Arch Med Wewn; 1995 Feb; 93(2):107-13. PubMed ID: 7479227.
    Abstract:
    UNLABELLED: Two groups of subjects (uraemic and control) were studied. The group A consisted of 20 patients treated by HD (haemodialysis). The mean age was x +/- SD--36.6 +/- 7.3 years, duration of haemodialysis treatment 32.8 +/- 7.7 months, cuprophan dialyzers and acetate containing solution--35 mEq/l--were used, time of HD--4 hours 3 times weekly, predialysis serum creatinine was 876 +/- 189 mumol/l (9.8 +/- 2.1 mg%). This group of patients was subdivided in two groups. The group I comprised 9 patients with hypotensive episodes that occurred during HD (systolic blood pressure < 90 mmHg), and the group II comprised 11 patients without hypotensive episodes. The control group comprised 20 healthy subjects (mean age 36.7 +/- 12.1 years, serum creatinine level 77 +/- 16 mumol/l (0.9 +/- 0.2 mg%). In all examined subjects the following experimental protocol was used. Blood pressure (BP) was determined at about 8 a.m. after an overnight rest. Then blood samples were withdrawn for estimation of ANP, haematocrit value (Ht), haemoglobin (Hb) and creatinine concentrations. Between 8 and 12 a.m. all examined uraemic subjects were dialyzed. After each hour of dialysis BP was measured and blood samples were taken. ANP (Peninsula Lab.Kids.) was measured using RIA method, and other biochemical parameters using routine methods. Serum creatinine and plasma ANP levels significantly decreased after HD. No significant differences were seen between the both uraemic groups. No significant correlations between systolic blood pressure, ANP level in examined group were observed. CONCLUSIONS: 1. In all uraemic subjects, plasma ANP level was significantly higher than in control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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