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  • Title: Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
    Author: Miller RD, Hogg J, Ozaki JH, Gell D, Jackson SP, Riblet R.
    Journal: Proc Natl Acad Sci U S A; 1995 Nov 07; 92(23):10792-5. PubMed ID: 7479885.
    Abstract:
    The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.
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