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  • Title: [Characterization of mutation of the P53 gene in lymphomas].
    Author: Martínez-Delgado B, Robledo M, Arranz E, Rivas C, Benítez J.
    Journal: Sangre (Barc); 1995 Aug; 40(4):301-5. PubMed ID: 7482119.
    Abstract:
    PURPOSE: To analyze P53 mutations in a series of NHL and to determine its implication in the inactivation of the tumor suppressor function. MATERIAL AND METHODS: We analyzed 18 lymphomas by SSCP (exons 5 to 9) and subsequent sequencing technics to detect and characterize mutations on this gene. Loss of heterozigosity (LOH) was also studied with a VNTR near the p53 gene and with a intragenic microsatellite, comparing tumor and normal tissue. RESULTS: We found altered bands by SSCP in 5 cases, 4 of them have been described by sequencing analysis. One case was a polymorphism and the others were missense mutations. All mutations appeared in high grade lymphomas. Only one case showed LOH in both VNTR and microsatellite. CONCLUSIONS: This results suggest that p53 mutations may be associated with more malignant lymphomas.
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