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  • Title: [Errors in the diagnosis and therapy of chronic lympholeukemias].
    Author: Iakhnina EI, Astsaturov IA, Pivnik AV, Samoĭlova RS, Kremenetskaia AM, Vorob'ev AI.
    Journal: Ter Arkh; 1995; 67(7):45-9. PubMed ID: 7482305.
    Abstract:
    The analysis of 67 cases of benign, progressive, tumor CLL, lymph node lymphocytoma, CLL sarcoma transformation showed that the cases were misdiagnosed in 35.8% cases. The most common mistake (25.4%) was aggressive chemotherapy based on histological diagnosis of prolymphocytic, prolymphocytic-lymphoblastic lymphosarcoma without consideration of cytological and clinical evidence, tumor phenotype. The authors think valid to use the following criteria in diagnosis of lymphoproliferative diseases: histological findings, clinical manifestations and blood picture, tumor cell cytology, primary location and predominant dissemination of the tumor, immunophenotype, characteristic chromosomal disorders, response to treatment.
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