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  • Title: [Corticosteroid therapy and aseptic bone necrosis in patients with rheumatoid arthritis].
    Author: Tsurko VV, Ivanova MM, Tokmachev IuK.
    Journal: Ter Arkh; 1995; 67(7):71-4. PubMed ID: 7482313.
    Abstract:
    Two groups of RA patients were compared: 102 patients with osteonecrosis of the head of the femur (group 1) and 50 patients free of it (group 2). Group 1 patients had bilateral lesion of the hip joints (28% of cases), unilateral osteonecrosis of knee joint in 14.5% and bilateral in 2.9% of the patients. Unilateral humeral osteonecrosis occurred in 17.6%, bilateral in 4.9% of patients. Extra-articular manifestations of RA (lymphadenopathy, renal lesions and Cushing's syndrome) were diagnosed more frequently in group 1. Progression of osteonecrosis is related to a mean maximal day dose of prednisolone in the first month of therapy.
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