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  • Title: Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin.
    Author: Heindel JJ, Williams E, Robison GA, Strada SJ.
    Journal: J Cyclic Nucleotide Res; 1978 Dec; 4(6):453-62. PubMed ID: 748397.
    Abstract:
    Somatostatin inhibits basal and chlorpromazine stimulated adenylyl cyclase activity in homogenates of GH1 rat pituitary tumor cells. The Dtryp8-Dcys14 analogue is more potent than tyrosyl somatostatin as an inhibitor of both basal and chlorpromazine-stimulated adenylyl cyclase. Somatostatin had no effect on sodium fluoride or quanylyl-imidodiphosphate-stimulated cyclase in GH1 cell homogenates or on basal, epinephrine or prostaglandin E1 stimulated cyclase activity in sonicated BHK fibroblasts. These results indicate a specific effect of somatostatin to inhibit pituitary adenylyl cyclase activity.
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