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  • Title: Lymphocytosis of large granular lymphocytes in patients with Hodgkin's disease.
    Author: Kingreen D, Dalal BI, Heyman M, Phillips GL, Horsman D, Kidd P, Loughran TP.
    Journal: Am J Hematol; 1995 Dec; 50(4):234-6. PubMed ID: 7485096.
    Abstract:
    Clonal disorders of large granular lymphocytes (LGL) of either CD3- (NK cell) or CD 3+ (T-cell) phenotype have been described. B-cell malignancies such as hairy cell leukemia and non-Hodgkin's lymphoma have been observed in association with the T-cell type of LGL leukemia. Here we report the occurrence of LGL lymphocytosis in four patients with Hodgkin's disease. Immunophenotyping studies showed that these LGL were CD 3- in three patients and CD3+ in the other. LGL were polyclonally expanded in both patients in whom clonality could be assessed.
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