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  • Title: [Adrenergic betablockers and heart failure].
    Author: Lechat P.
    Journal: Arch Mal Coeur Vaiss; 1995 Apr; 88(4 Suppl):611-5. PubMed ID: 7487311.
    Abstract:
    Several studies have shown that beta-blockade could provide functional benefit in heart failure, suggesting a deleterious role for the compensatory sympathetic stimulation. Betablockers induced benefit could result from either antagonism of myocardial beta-adrenergic stimulation or, on the contrary a paradoxical increased cardiac beta-adrenergic responsiveness secondary to beta-adrenergic receptor up-regulation. Two recently completed large scale multicentric placebo controlled studies, the MDC trial with metoprolol and CIBIS with bisoprolol, have confirmed that beta-blockade could functionally improve patients with heart failure. The observed survival improvement in non-ischaemic patients was observed only in the CIBIS trial. This result requires confirmation by additional studies.
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