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  • Title: Expression of alpha-fetoprotein by ovarian Sertoli-Leydig cell tumors. Case report and review of the literature.
    Author: Hammad A, Jasnosz KM, Olson PR.
    Journal: Arch Pathol Lab Med; 1995 Nov; 119(11):1075-9. PubMed ID: 7487411.
    Abstract:
    A 17-year-old girl had an ovarian Sertoli-Leydig cell tumor associated with elevation of the serum alpha-fetoprotein level. On microscopic examination, the tumor had a predominantly spindled cellular stroma containing open and solid tubules, focal clusters of hepatoid cells, and heterologous carcinoid. Alpha-fetoprotein was demonstrated within the hepatoid cells by immunohistochemical techniques. After surgery, serum alpha-fetoprotein level fell to normal, and the patient is still free of tumor 8 months later.
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