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  • Title: A radioimmunoassay for prostatic acid phosphatase.
    Author: Cooper JF, Foti AG.
    Journal: Natl Cancer Inst Monogr; 1978 Dec; (49):235-7. PubMed ID: 748776.
    Abstract:
    A solid phase radioimmunoassay for human prostatic acid phosphatase has demonstrated substantially greater biochemical sensitivity than a standard enzymatic method for which p-nitrophenylphosphate was used as substrate. Preliminary data indicate that the radioimmunochemical approach can precisely classify 43% stage I-II and 94% stage III-IV prostate cancers. In contrast, the standard enzymatic methods correctly classified only 9% stage I-II and 46% stage III-IV cancers. It is clinically apparent that a radioimmunochemical approach for the measurement of human prostatic phosphatase may have distinct potential in the clinical diagnosis of prostate cancer.
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