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  • Title: A brain-specific G protein gamma subunit.
    Author: Kalyanaraman S, Kalyanaraman V, Gautam N.
    Journal: Biochem Biophys Res Commun; 1995 Nov 02; 216(1):126-32. PubMed ID: 7488078.
    Abstract:
    Two different cDNAs for G protein gamma subunits have been isolated from mouse brain. One encodes a novel gamma subunit, gamma 4, the expression of which is detected only in brain. A fragment of this cDNA had been isolated previously. The other cDNA encodes gamma 3, a subunit type previously isolated from bovine brain. The primary structure of the gamma 3 subunit is conserved completely across species indicating that the diversity in the structure of the gamma subunits is of functional consequence. Moreover, gamma 2, gamma 3 and gamma 4, which are predominantly expressed in brain, are more homologous to each other than other gamma subunits, indicating that the G protein gamma subunits belong to distinct subfamilies similar to the alpha subunits.
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