These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cocaine self-administration and naltrindole, a delta-selective opioid antagonist.
    Author: Reid LD, Glick SD, Menkens KA, French ED, Bilsky EJ, Porreca F.
    Journal: Neuroreport; 1995 Jul 10; 6(10):1409-12. PubMed ID: 7488736.
    Abstract:
    Recent reports from several laboratories have suggested a role for delta opioid receptors in expressing some of the biochemical and behavioral effects of cocaine. Here, this possibility has been further explored by evaluating the propensity of rats to self-administer i.v. cocaine in the absence or presence of naltrindole, a selective delta opioid antagonist. Following a number of days of stable cocaine intake, and before a day's session, naltrindole (3 or 10 mg kg-1) reduced pressing for cocaine, regardless of the schedule of reinforcement. These data further support the role of processes associated with delta opioid receptors in the ability of cocaine to reinforce its own use.
    [Abstract] [Full Text] [Related] [New Search]