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  • Title: [The long-term depression of the function of the hypothalamo-hypophyseal-adrenocortical system in rats].
    Author: Filaretova LP, Podvigina TT, Bagaeva TR, Filaretov AA.
    Journal: Fiziol Zh Im I M Sechenova; 1995 Jan; 81(1):24-31. PubMed ID: 7489010.
    Abstract:
    Hypothalamo-pituitary-adrenocortical axis reactivity was studied in vivo and in vitro in 7 days after single administration of 30 mg/100 g body weight of hydrocortisone in rats. There were a blockade of stress-induced decrease of CRF-41 content in median eminence, and failure of increase of ACTH and corticosterone levels in the blood to stress in 7 days after hydrocortisone administration. A decrease of reactivity to ACTH was shown during incubation of adrenals from rats treated with hydrocortisone. 300 and 400 mg/100 g body weight of corticosterone s. c. imitates a stress-induced increase of corticosterone in the blood and can be used as replacement therapy. We conclude that high supraphysiological doses of glucocorticoids results in a decrease of reaction of hypothalamus, pituitary and adrenals to stress.
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