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  • Title: Formation of 5-hydroxy-5,6-dihydrouracil and release of undamaged uracil as a result of poly(U) irradiation in N2O-saturated aqueous solution.
    Author: Grachev SA, Kropachev EV, Litvjakova GI.
    Journal: Int J Radiat Biol; 1995 Nov; 68(5):543-51. PubMed ID: 7490504.
    Abstract:
    The radiation chemical yields of 5-hydroxy-5,6-dihydrouracil and uracil were measured on radiolysis of N2O-saturated solutions containing I mmol dm-3 poly(U) and were found to be 0.04 and 0.31 mumol J-1 respectively. From the 5-hydroxy-5,6-dihydrouracil yield in the presence of cysteamine and 2-mercaptoethanol, it is shown that only 20% of the OH-radicals, which attack poly(U) results in the formation of 5-hydroxy uracil adducts. It has been proposed that as yet unknown reducing radicals are formed in addition to known reducing radicals (the 5-OH-adducts of uracil, the H-adducts of uracil, and sugar radicals) as a result of the reaction of OH-radicals with poly(U).
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