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  • Title: Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence.
    Author: Kriegmair M, Baumgartner R, Knüchel R, Stepp H, Hofstädter F, Hofstetter A.
    Journal: J Urol; 1996 Jan; 155(1):105-9; discussion 109-10. PubMed ID: 7490803.
    Abstract:
    PURPOSE: We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence. MATERIALS AND METHODS: A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.). RESULTS: The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity. CONCLUSIONS: Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies.
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