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  • Title: Determining the origin of hematuria by immunocytochemical staining of erythrocytes in urine for Tamm-Horsfall protein.
    Author: Fukuzaki A, Kaneto H, Ikeda S, Orikasa S.
    Journal: J Urol; 1996 Jan; 155(1):248-51. PubMed ID: 7490846.
    Abstract:
    PURPOSE: We analyzed the feasibility of immunocytochemical staining of urinary erythrocytes for Tamm-Horsfall protein to differentiate renal from nonrenal hematuria. MATERIALS AND METHODS: Urine samples collected from 74 patients with hematuria were evaluated. Erythrocytes in urine were inspected morphologically and the same samples were immunocytochemically stained with antibody against human Tamm-Horsfall protein. RESULTS: Erythrocytes in urine were clearly stained for Tamm-Horsfall protein in renal hematuria. Tamm-Horsfall protein immunocytochemistry was more consistent with clinical diagnosis than morphology. CONCLUSIONS: Immunocytochemical staining of urine erythrocytes for Tamm-Horsfall protein appears to be a reliable tool to differentiate renal from nonrenal hematuria.
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