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  • Title: Protective effect of verapamil on regional myocardial ischaemic injury in dog.
    Author: Kobusiewicz W, Ogonowska-Kobusiewicz M, Michalak J, Zywicki W, Ledwozyw A.
    Journal: Acta Vet Hung; 1995; 43(2-3):311-20. PubMed ID: 7491871.
    Abstract:
    Ischaemic injury was produced in the dog heart by occluding the left anterior descending coronary artery just below the second diagonal branch for 3 h. Verapamil 5.0 mg/kg was injected intravenously 10 min before the occlusion. There was some decrease in ATP and creatine phosphate levels in the hearts of "no drug" animals as compared to sham-operated dogs. Verapamil significantly increase the level of these metabolites. The ATP/ADP ratio decreased from 8.5 +/- 0.60 in hearts from sham-operated dogs to 3.5 +/- 0.30 in the "no drug" group. Verapamil pretreatment resulted in values of the ATP/ADP ratio which were lower than, but not significantly different from, those observed in the control group. In ischaemic mitochondria the calcium content (Ca++) increased significantly as compared to the control and the Verapamil group. A significant increase in free fatty acid content in myocardial membrane preparations was also observed as compared to the sham-operated and the Verapamil group.
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