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  • Title: Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
    Author: Reyna F, Huesca M, González V, Fuchs LY.
    Journal: Antimicrob Agents Chemother; 1995 Jul; 39(7):1621-3. PubMed ID: 7492118.
    Abstract:
    Spontaneous quinolone-resistant mutants obtained from Salmonella typhimurium Su694 were screened for mutations by direct DNA sequencing of an amplified PCR gyrA fragment. Substitutions Ser-83-->Phe (Ser83Phe), Ser83Tyr, Asp87Tyr, and Asp87Asn and double mutation Ala67Pro-Gly81Ser, which resulted in decreased sensitivities to ciprofloxacin, enoxacin, pefloxacin, norfloxacin, ofloxacin, and nalidixic acid, were found. The levels of resistance to quinolones for each mutant were determined.
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