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  • Title: The effects of paraquat on prostaglandin synthesis of guinea pig lungs.
    Author: Giri SN, Krishna G.
    Journal: Toxicology; 1978 Dec; 11(4):345-51. PubMed ID: 749272.
    Abstract:
    The effects of paraquat treatment (10 mg/kg i.p.) on the prostaglandin synthesizing ability of guinea pig lungs were examined in the present study. It was observed that paraquat-treated animals, as compared to controls, had a significantly reduced ability to synthesize PGF2 alpha and "PGE2" at 24 and 48 h after the treatment. Paraquat, however, failed to have any effect on prostaglandin synthesis in vitro. A decrease in the ability of prostaglandin synthesis in paraquat-treated guinea pig lung was attributed possibly to a decrease in the amount of lung microsomal protein.
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