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  • Title: t(8;21) breakpoints are clustered between alternatively spliced exons of MTG8.
    Author: Tighe JE, Calabi F.
    Journal: Clin Sci (Lond); 1995 Sep; 89(3):215-8. PubMed ID: 7493414.
    Abstract:
    1. The (8;21) translocation, which is consistently associated with a subgroup of acute myeloid leukaemia, involves two loci: runt on chromosome 21 and MTG8 on chromosome 8. 2. Breakpoints in runt fall within a single intron that is located immediately downstream of a phylogenetically conserved DNA-binding domain (the 'runt box'). 3. We now show that most breakpoints on chromosome 8 fall within a region between two alternative 5' MTG8 exons. Thus, we predict that chimaeric genes on both the derivative(8) and the derivative(21) chromosomes have the potential to be transcriptionally active.
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