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  • Title: Immunoepidemiology of human necatoriasis: correlations between antibody responses and parasite burdens.
    Author: Quinnell RJ, Woolhouse ME, Walsh EA, Pritchard DI.
    Journal: Parasite Immunol; 1995 Jun; 17(6):313-8. PubMed ID: 7494644.
    Abstract:
    In this paper we describe the relationship between antibodies to Necator americanus stage-specific antigens and parasite burden in an endemically-infected population in Papua New Guinea. Using an age-structured analysis, we show that the correlation coefficient between levels of IgG against adult worm excretory-secretory (ES) antigen and parasite burden declined significantly with host age from positive in younger hosts to significantly negative in older hosts. A trend towards similar patterns was present for anti-larval IgG both pretreatment and after reinfection, and for anti-ES IgM and anti-ES IgE pretreatment. These patterns are consistent with a role for these isotypes in a protective immune response, although parasite-induced immunosuppression may provide an alternate explanation. This is another demonstration of possibly protective responses to N. americanus infection.
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