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  • Title: Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein.
    Author: Thomas SR, Neuzil J, Mohr D, Stocker R.
    Journal: Am J Clin Nutr; 1995 Dec; 62(6 Suppl):1357S-1364S. PubMed ID: 7495231.
    Abstract:
    The oxidation of low-density lipoproteins (LDLs) is now commonly implicated as an important early event in atherogenesis. The resulting interest in LDL antioxidation has focused on alpha-tocopherol, the biologically and chemically most active form of vitamin E and quantitatively the major lipid-soluble antioxidant in extracts prepared from human LDL. We review advances made in our understanding of the molecular action of alpha-tocopherol in radical-mediated oxidation of isolated human LDL and how the vitamin's antioxidant activity is enhanced or even dependent on the presence of suitable reducing species, which are referred to as coantioxidants.
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