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  • Title: [Rational concepts and the study of active molecules against various trypanosomiases].
    Author: Périé J, de Albuquerque C, Blonski C, Chauvière G, Gefflaut T, Page P, Trinquier M, Willson M.
    Journal: Bull Soc Pathol Exot; 1994; 87(5):353-61. PubMed ID: 7496200.
    Abstract:
    Several sets of compounds, active against different trypanosomes, Trypanosoma brucei and Trypanosoma cruzi are presented, the lethal doses for some of them being less than the micro-molar concentration. These compounds are designed by taking advantage of two metabolic features of these parasites, glucose metabolism and oxidative stress.
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