These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The effect of 5-fluorouracil on the clonogenic hematopoietic cells (CFU-S) of embryonic and sexually mature mice].
    Author: Domaratskaia EI, Starostin VI, Prianishnikova OD.
    Journal: Izv Akad Nauk Ser Biol; 1995; (4):398-402. PubMed ID: 7496312.
    Abstract:
    We studied sensitivity of various types of clonogenic hemopoietic cells (CFU-S-7, CFU-S-11, and CFU-ep) on the liver of 14-days embryos and from the bone marrow and spleen of adult mice to the cytotoxic agent 5-fluorouracil (5-FU) in vitro and in vivo. We discovered that different types of CFU-S of the embryos and adult mice has similar sensitivity to 5-FU in vitro. At the same time in vivo the bone marrow CFU-S-7 display a higher sensitivity to 5-FU than CFU-S-11, thus agreeing with the published data (Hodgson and Bradley, 1979). The differences between the 5-FU effects in vitro and in vivo are related to the hemopoietic microenvironment, which modulates the cytotoxic 5-FU effect in vivo.
    [Abstract] [Full Text] [Related] [New Search]