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  • Title: Ascites free-water dynamics in decompensated cirrhosis: effects of acute and chronic frusemide treatment.
    Author: Milani A, Ciammella AM, Rossi L.
    Journal: Eur J Gastroenterol Hepatol; 1995 Aug; 7(8):763-7. PubMed ID: 7496866.
    Abstract:
    OBJECTIVE: To evaluate the effects of acute (60 mg intravenous bolus) and protracted (75 mg per day orally for 1 week) frusemide administration on ascites volume, free-water peritoneal clearance (FWPC), intra-abdominal pressure (IAP) and body weight in 30 decompensated cirrhotic patients. METHODS: Individual ascites volume and FWPC were estimated by means of a previously validated methylene-blue dilution test. RESULTS: All the investigated parameters showed a significant reduction after the protracted diuretic treatment (ascites volume 9.0 +/- 1.0 to 4.9 +/- 0.61, P < 0.001; FWPC 99.8 +/- 6.7 to 76.2 +/- 6.6 ml/min, P < 0.001; IAP 17.0 +/- 1.5 to 11.3 +/- 0.8 cmH2O, P < 0.001; body weight 75.2 +/- 1.9 to 66.3 +/- 1.8 kg, P < 0.001). A significant FWPC reduction (89.5 +/- 14.6 to 68.8 +/- 12.1 ml/min, P < 0.02) was also observed after the acute frusemide administration in the absence of any appreciable modifications to ascites volumes and IAP. CONCLUSION: Frusemide treatment appears to be able to exert a direct significant effect on FWPC, which does not appear to be mediated by ascites volume or IAP modifications.
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