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  • Title: Undefined malabsorption syndrome with villous atrophy successfully reversed by treatment with cyclosporine.
    Author: Eijsbouts AM, Witteman BJ, de Sévaux RG, Fennis JF, van Haelst UJ, Naber AH, Jansen JB.
    Journal: Eur J Gastroenterol Hepatol; 1995 Aug; 7(8):803-6. PubMed ID: 7496873.
    Abstract:
    A 47-year-old man with a flat jejunal mucosa complicated by malabsorption, diarrhoea and lymphocytic colitis is presented. There was no response to gluten withdrawal alone, combination of a gluten-free diet and prednisone therapy, or total parenteral nutrition. Complete clinical remission was only achieved after simultaneous treatment with cyclosporine and a gluten-free diet. Rechallenge with a gluten-containing diet while cyclosporine treatment continued resulted in a relapse of diarrhoea and malabsorption. We conclude that cyclosporine may be an effective agent for the treatment of undefined, refractory forms of malabsorption.
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