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  • Title: The stimulatory effect of human PMNI lysosomes on lymphocytes in vitro and in vivo.
    Author: Tchórzewski H, Sułowska Z, Soszyńska W.
    Journal: Arch Immunol Ther Exp (Warsz); 1978; 26(1-6):449-53. PubMed ID: 749796.
    Abstract:
    The proteins isolated from human PMNL lysosome granules have activated the lymphocytes in vitro. It was found that T cells undergo transformation in response to lysosome mitogens but no LIF production was observed. Transformation induced by PHA, PWM and Con A was depressed in the presence of lysosome mitogens. The in vivo response to T-dependent antigens is amplified by lysosome mitogens. The above experiments demonstrate that lysosome mitogens stimulate T lymphocytes.
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