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  • Title: Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.
    Author: Aceto MD, Scates SM, Lowe JA, Martin BR.
    Journal: Eur J Pharmacol; 1995 Aug 25; 282(1-3):R1-2. PubMed ID: 7498260.
    Abstract:
    Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole carboxamide.HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids.
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