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  • Title: Influence of the cysteine derivatives on the cell-mediated immunity.
    Author: Ryzewski J, Kossakowska M, Krzystyniak K.
    Journal: Arch Immunol Ther Exp (Warsz); 1978; 26(1-6):913-6. PubMed ID: 749839.
    Abstract:
    The immunosuppressive action of N,N, S-trimethyl-cysteine, S-methyl-L-cysteine hydrazide hydrochloride and L-cysteine hydrazide on the course of post-adjuvant polyarthritis, graft-versus-host reaction, turpentine oedema and incorporation of 3H-thymidine into spontaneous or PHA stimulated lymphocyte cultures was examined. Inhibition of post-adjuvant polyarthritis and prolongation of skin allograft survival time were observed. L-cysteine hydrazide had shown the most inhibiting action. In vitro, S-methyl-L-cysteine hydrazide hydrochloride decreased and N,N, S-trimethyl-cysteine increased the incorporation of 3H-thymidine into the lymphocyte cultures stimulated by PHA. The obtained results were compared with the action of DL-cysteine hydrochloride.
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