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  • Title: Mono-, di- and trimeric binding of a bis-netropsin to DNA.
    Author: Zasedatelev AS, Borodulin VB, Grokhovsky SL, Nikitin AM, Salmanova DV, Zhuze AL, Gursky GV, Shafer RH.
    Journal: FEBS Lett; 1995 Nov 20; 375(3):304-6. PubMed ID: 7498523.
    Abstract:
    An unusual 3:1 stoichiometry for complex formation between an elongated bis-netropsin compound and its binding site on DNA has been observed. Circular dichroism measurements distinguish two types of complexes formed between this bis-netropsin and poly[d(A-T)].poly[d(A-T)]. The first type is characterized by a 1:1 saturating ratio of bound molecules per ten base pairs. Formation of the second type results from the cooperative binding of two additional bis-netropsin molecules to the first type of complex. In contrast to these results observed for binding to the alternating polynucleotide, only the 1:1 type of complex is formed when this ligand binds to the homopolymer poly(dA).poly(dT).
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