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  • Title: GLUT-3 (brain-type) glucose transporter polypeptides in human blood platelets.
    Author: Craik JD, Stewart M, Cheeseman CI.
    Journal: Thromb Res; 1995 Sep 15; 79(5-6):461-9. PubMed ID: 7502272.
    Abstract:
    Antiserum directed against a C-terminal peptide of the human GLUT-3 (brain type) equilibrative glucose transporter isoform reacted with polypeptides M(r) 46,000-48,000 on immunoblots of human platelets. Photoirradiation of human platelets in the presence of 3H-cytochalasin B led to radiolabeling of polypeptides of identical mobility. This labeling was substantially reduced by preincubation the cells with 440 mM D-glucose, but not 440 mM L-glucose, consistent with glucose transporter function. Only traces of GLUT-1 (erythrocyte type) glucose transporter polypeptides were detected, and there was no evidence of GLUT-2 (liver type) transporter on immunoblots of platelet proteins.
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