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  • Title: Methotrexate-induced leukoencephalopathy. A case report.
    Author: Ilhan I, Cila A, Büyükpamukçu M, Akyüz C, Kutluk T, Berberoğlu S.
    Journal: Turk J Pediatr; 1995; 37(3):275-8. PubMed ID: 7502368.
    Abstract:
    A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic resonance imaging (MRI). Treatment-related leukoencephalopathy is one such adverse effect of IT methotrexate administration on the central nervous system and usually appears in a generalized form.
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